Thermodynamic Parameters of Cis-Platin and Trans-Platin Complexes with Guanine in Water, A DFT Study
Authors
Abstract:
The binding energy and Thermodynamic Parameters of cis- Platinum Di Ammino Chlorine (cis-[Pt(NH3)2Cl]+) and trans- Platinum Di Ammino Chlorine (trans- [Pt(NH3)2Cl]+) complexes withGuanine has been studied by density functional theory (DFT) calculations in water. The bindingenergies (Ebin) of cis- and trans-[Pt(NH3)2ClG]+ are calculated to be 79.38 kcal/mol and 74.98kcal/mol, respectively. The binding energy (Ebin) of cis-[Pt(NH3)2ClG]+ turns out to be energeticallymore favorable by about 1.88 kcal/mol than the trans-[Pt(NH3)2Cl]+. At the point of thermodynamic,the formation of cis-[Pt(NH3)2ClG]+(aq)with G (Solv) equal to -10.36 kcal/mol is more favorablethan trans-[Pt(NH3)2ClG]+(aq) with 16.21 kcal/mol.
similar resources
thermodynamic parameters of cis-platin and trans-platin complexes with guanine in water, a dft study
the binding energy and thermodynamic parameters of cis- platinum di ammino chlorine (cis-[pt(nh3)2cl]+) and trans- platinum di ammino chlorine (trans- [pt(nh3)2cl]+) complexes withguanine has been studied by density functional theory (dft) calculations in water. the bindingenergies (ebin) of cis- and trans-[pt(nh3)2clg]+ are calculated to be 79.38 kcal/mol and 74.98kcal/mol, respectively. the b...
full textMicroRNA signature of cis-platin resistant vs. cis-platin sensitive ovarian cancer cell lines
BACKGROUND Ovarian cancer is the leading cause of death from gynecologic cancer in women worldwide. According to the National Cancer Institute, ovarian cancer has the highest mortality rate among all the reproductive cancers in women. Advanced stage diagnosis and chemo/radio-resistance is a major obstacle in treating advanced ovarian cancer. The most commonly employed chemotherapeutic drug for ...
full textA theoretical study of the stability of DNA binding with cis/trans platin.
Both cis- and trans-platins are known to form intra- and interstrand cross-linking with DNA. Since the nature and strength of binding is different, it makes their efficacy as anti-tumour drug different. In the present communication, we report theoretical analysis by using an amended Zimm and Bragg theory, to explain the melting behaviour and heat capacity of DNA with and without platin binding....
full textInduction of micronuclei in a transplantable murine tumor after multimodality treatment with cis-platin, radiation and hyperthermia
Background: Tumor response after multimodality treatment using combination of radiation, chemotherapeutic drugs and hyperthermia usually assessed by parameters such as tumor growth delay, volume doubling time and regression response. The study herein was conducted to investigate the usefulness of micronucleus assay for assessing the multimodality treatment. Materials and Methods: The ...
full textIsomer-dependent adsorption and release of cis- and trans-platin anticancer drugs by mesoporous silica nanoparticles.
We report on adsorption and release of the anticancer drugs cisplatin and transplatin from mesoporous silica nanomaterials, emphasizing the differences between cisplatin and its much less toxic isomer. Two types of particles, MCM-41 and SBA-15, were used, either as just synthesized or after calcination to remove the templates. The particles were characterized by TEM, nitrogen physisorption, and...
full textCis-platin responsive sequences in the human c-myc promoter.
We have transfected recombinant plasmids carrying 5' c-myc sequences linked to the reporter gene chloramphenicol acetyl-transferase (cat) and to the selectable marker aminoglycoside phosphotransferase (aph) into rat fibroblasts and obtained stable transfectants. The response to cis-platin of these cell lines was studied. At 5 X 10(-5) M concentration cis-platin stimulates cat gene expression 9 ...
full textMy Resources
Journal title
volume 10 issue 4
pages 211- 214
publication date 2014-01-01
By following a journal you will be notified via email when a new issue of this journal is published.
Hosted on Doprax cloud platform doprax.com
copyright © 2015-2023